WebRoman Christian Hillig, Benjamin Bader, in Advances in Cancer Research, 2024. 2 SOS1 as a molecular target for cancer therapy. The idea of targeting SOS1 as an indirect way …
Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to …
WebMar 16, 2011 · Brefeldin A (BFA) is a fungal metabolite that interrupts trafficking between the Golgi apparatus and the ER, leading to the accumulation of secretory proteins in the ER [40,54]. Treatment with BFA results in uncoating of the Golgi apparatus [ 55 ] and subsequent formation of tubulovesicular processes that redistribute the contents of the … WebDec 28, 2024 · Numerous cancer cell lines, including breast (Sewell et al., 2006), colon (Kellokumpu et al., 2002), and prostate cancer cells (Nolfi et al., 2024), exhibit fragmented Golgi. ... Treating cells with Brefeldin A activates the CREB3-ARF4 pathway and inhibits the function of ARF proteins. filebrowser ipk
Brefeldin A (BFA) Protein Transport Inhibitor MedChemExpress
WebJul 5, 2013 · Brefeldin A induces apoptosis in various cancer cells; however, the apoptotic process in cancer cells exposed to brefeldin A remains unclear. In addition, it is unclear whether brefeldin A-induced apoptosis is mediated by the formation of … WebBrefeldin A is a potent inhibitor of protein trafficking from the ER to the Golgi apparatus. Brefeldin A inhibits the translocation of STING to the ERGIC, thereby blocking STING-induced type I IFN production. … WebMar 7, 2016 · In the present study, we analyzed the influence of brefeldin A (BFA) and castanospermine (CAS) on the activity, stability and localization of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in various resistant cell lines. The impact of BFA and CAS on cell viability was assessed using the MTT test. grocery store joshua tree