Cholera toxin phage

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August undefined, 2024

http://www.als-journal.com/1013-23/ WebVaxchora (lyophilized CVD 103-HgR) is a single-dose, oral vaccine FDA- approved in the United States for use in people aged 2–64 who are traveling to an area of active cholera …

The role of bacteriophages transferring virulence factors to ...

WebMay 27, 1999 · Over 100 years ago, V. cholerae was identified as the bacterial species that causes the deadly, infectious diarrhoeal disease cholera 2. More recently, the potent … WebFeb 28, 2024 · The disease is the principal manifestation of a potent toxin known as cholera toxin, produced by the bacteria. Generation of a toxin producing V. cholerae … jess ogan

Lysogenic Conversion by a Filamentous Phage Encoding Cholera Toxin

WebAug 29, 2024 · The structural genes of cholera toxin are encoded by the filamentous phage CTXφ, and the CTXφ genome acts as a plasmid for chromosome integration or replication. The El Tor mutation of the phage CTXφ destroys XerC and XerD, two bacterial-encoded tyrosine recombinases. WebJan 21, 2010 · Cholera toxin, which is responsible for the deadly diarrhea associated with the disease of the same name, is one of the most significant virulence factors of Vibrio … WebJun 1, 2002 · Recent evidence demonstrates that non-toxigenic environmental strains can be converted by phage transduction with cholera toxin (CT)-encoding phage CTXφ, and this event could conceivably also take place in the gastrointestinal environment, ... The role of this toxin in cholera is unclear because classical strains appear to lack functional RTX. jess o gara

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Webtoxin definition: 1. a poisonous substance, especially one produced by bacteria, that causes disease 2. a poisonous…. Learn more. WebToxin-mediated illnesses, including as botulism, cholera, diarrhoea, diphtheria, and scarlet fever, are caused by toxins encoded by phages [40]. Virulence genes at E. coli phage specially Stx, can causes attaching and effacing (A/E) lesions, bloody diarrhoea and haemolytic uremic syndrome (HUS) [2]. jess of jesmond instagramWebAmong the more than 200 serogroups that comprise the V. cholerae species, only serogroups O1 and O139 typically carry the cholera toxin genes. Cholera toxin (CT) is an 84-kd heterodimer composed of 5 B subunits that encircle a single A subunit. The B subunit is responsible for binding to the monoganglioside GM1 receptor on intestinal epithelial ... jess o brian

"WebNov 1, 1996 · The transfer of cholera toxin genes by a phage that attaches to a specific pilus on the host bacterium may also account, at least in part, for the extraordinarily restricted host range of toxigenic Vibrio cholerae O1. Like most Vibrio species, these strains appear to be adapted to the estuarine environment and to invertebrate marine hosts. On ... " - Cholera toxin phage

Cholera toxin phage

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Webcholera definition: 1. a serious infection of the bowels caused by drinking infected water or eating infected food…. Learn more. WebThe genes that encode these exotoxins are frequently encoded by mobile DNA elements such as plasmids or phage. Mobile DNA elements can move exotoxin genes among microbial hosts, converting avirulent bacteria into pathogens. ... Cholera Toxin / genetics DNA, Bacterial / analysis DNA, Bacterial / isolation & purification ...

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WebAug 15, 2002 · CTXphi is a filamentous bacteriophage whose genome encodes cholera toxin, the principal virulence factor of Vibrio cholerae. We have found that the CTXphi-related element RS1 is a satellite phage whose transmission depends upon proteins produced from a CTX prophage (its helper phage). However, unlik … WebAug 16, 2024 · In particular, cholera toxin, the principal virulence factor of Vibrio cholerae, is encoded in the genome of an IMEX, the cholera toxin phage, CTXΦ (5–8). Nontoxigenic V. cholerae strains generally lack a suitable CTXΦ attachment site. In addition, CTXΦ integration is intrinsically irreversible.

WebThis cholera toxin contains 5 B subunits that plays a role in attaching to the intestinal epithelial cells and 1 A subunit that plays a role in toxin activity. ... CTXφ (also called CTXphi) is a filamentous phage that contains the genes for cholera toxin. Infectious CTXφ particles are produced when V. cholerae infects humans.

WebApr 5, 2024 · Furthermore, many other Vibrio phages and prophages interact with the CTXφ phage to promote the horizontal transfer of the cholera toxin genes (reviewed in detail by 36). The host receptor for the … WebMay 28, 2024 · Although ctxAB genes are crucial to V. cholerae strains for cholera manifestation, the genetic structure of cholera toxin phage, DNA sequence of its genes, spatial organization in the host genome and its satellite phage content are not …

WebOf 251 environmental non-O1, non-O139 strains tested, 10 (3.9%) carried the toxin coregulated pilus (TCP) pathogenicity island encoding TCPs, and the CTX prophage encoding cholera toxin, whereas another 10 isolates carried the TCP island alone, and were susceptible to transduction with CTX phage.

WebI have found and described a new mechanism of horizontal transmission for the cholera toxin genes; which is mediated by the V. cholerae filamentous bacteriophages VEJphi and VGJphi (ASM Annual ... jess odomWebRecently, V. cholerae serougroup O75 strains possessing the cholera toxin gene were isolated from patients with severe diarrhoea, ... Some serotypes may serve as a reservoir for the cholera toxin phage genome Footnote 6 Footnote 7. Serotypes that do not produce cholera toxin can still cause illness in humans (i.e. enteritis) Footnote 8. jess odinWebThe disease is the principal manifestation of a potent toxin known as cholera toxin, produced by the bacteria. Generation of a toxin producing V. cholerae strain arises by … jess oji