E2f factor
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the … See more Homo sapiens E2F1 mRNA or E2F1 protein sequences from NCBI protein and nucleotide database. See more X-ray crystallographic analysis has shown that the E2F family of transcription factors has a fold similar to the winged-helix DNA-binding motif See more The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription … See more • Transcription factor DP • Type 3c (Pancreatogenic) Diabetes See more • E2F+Transcription+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Drosophila E2F transcription factor - The Interactive Fly See more E2F family members play a major role during the G1/S transition in mammalian and plant cell cycle (see KEGG cell cycle pathway). DNA microarray analysis reveals unique sets of target promoters among E2F family members suggesting that each protein has a … See more • Cell cycle: CCNA1,2, CCND1,2, CDK2, MYB, E2F1,2,3, TFDP1, CDC25A • Negative regulators: E2F7, RB1, TP107, TP21 See more WebFunction [ edit] The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved ...
E2f factor
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WebMay 3, 2024 · The E2F family of transcription factors is encoded by eight genes whose protein products form a core transcriptional axis crucial for coordinating the oscillatory nature of the cell cycle 18.In ... WebMar 31, 2024 · The E2F component of these complexes contacts the DNA via E2F transcription factor binding sites in the gene promoters. RB-E2F complexes downregulate transcription of the genes [ 19 ].
WebMay 11, 2024 · E2F transcription factor 2 (E2F2) is a member of the E2F family of transcription factors. The classical view is that some E2Fs act as "activators" and others … WebIn turn, LMCD1 acted as a transcriptional coactivator of E2F transcription factor 1 to promote the transcription of TGF-β1. Moreover, TGF-β1 increased the interaction between LMCD1 and Smad ubiquitination regulatory factor 2 (Smurf2) and accelerated Smurf2-mediated LMCD1 degradation via the ubiquitination system.
WebNov 15, 2024 · The E2F-DP transcription factor family, widely distributed in variety of organisms, plays an important role in cell cycle regulation. In recent years, great progress has been made in the study of E2F-DP transcription factor members, as they have been identified from more and more species and their genetic functions have been studied. WebMar 31, 2024 · The E2F component of these complexes contacts the DNA via E2F transcription factor binding sites in the gene promoters. RB-E2F complexes …
WebThe subtle tuning of E2F levels by the MiR-20a/E2F loop was suggested to be the key factor deciding whether or not cells engage apoptosis (Sylvestre et al., 2007). Of note, …
WebThe target of retinoblastoma protein, E2F1, is a transcription factor whose expression is increased in many human cancers . [Review] High E2F1 expression is associated with metastasis in non-small cell lung cancers. E2F-1 inhibits growth of gastric cancer cells by regulating multiple signaling pathways. small red mark on palm of handWebMar 29, 2024 · The transcription factor E2F-1 plays a central role in the cell cycle through its ability to activate genes involved in cell division. E2F-1 activity is regulated by a number of proteins, including the retinoblastoma susceptibility gene product, cyclin-dependent kinases, and their inhibitors, proteins that have been implicated in the control of certain … small red meat plantWebAug 28, 2006 · Each of the E2F polypeptides can heterodimerize with either DP1 or DP2 (DP3) (Ormondroyd et al., 1995), although the E2F7 transcription factor binds DNA in a DP-independent manner. small red marks on armWebFeb 28, 2024 · The transcription factor E2F, the principal target of the RB pathway, plays central roles in cell proliferation by activating a repertoire of growth-related genes. Consistent with this, overexpression of E2F1, an activator type of E2F family members, in quiescent cells induces progression into S phase . Since E2F plays central roles in cell ... small red marks on faceWebIntroduction. E2Fs, as pivotal transcription factor members, play a critical role in regulating downstream genes transcription, DNA synthesis and cell cycle. 1 Mammalian E2F family … highlinerlodge.comWebThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor … highliner tavern seattleWebNov 10, 2024 · The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosis. Its crucial role in the control of cell fate has been extensively studied and reviewed before; however, here, we focus on the participation of E2F1 in the regulation of metabolism. We summarize recent findings … highliner seward ak