WebH2A.Z is an evolutionarily ancient and highly conserved H2A variant that regulates processes ranging from gene expression to the DNA damage response. Here we find that the unstructured portion of the C-terminal tail of H2A.Z is required for the normal functions of this histone variant in budding yeast. We have also identified a novel splice ... WebMar 21, 2024 · Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).
Mechanism of Polymerase II Transcription Repression by the …
WebJun 14, 2024 · The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not … WebMar 21, 2024 · H2AJ (H2A.J Histone) is a Protein Coding gene. Diseases associated with H2AJ include Diffuse Large B-Cell Lymphoma . Among its related pathways are RNA Polymerase I Promoter Opening and … sphera news
Histone Ubiquitination - an overview ScienceDirect Topics
WebJun 14, 2024 · The buffering functions of H2A.Z, as supported by genome-wide localization and analyzed in several dynamic systems, are an excellent example of transcriptional control. Posttranslational modifications such as acetylation and ubiquitination of H2A.Z, as well as its specific binding partners, are in our view central players in the control of gene ... WebJul 19, 2024 · The eutherian testis-specific histone variant H2A.B is aberrantly expressed in Hodgkin Lymphoma and enhances ribosomal biogenesis by stimulating both RNA Pol I transcription and the transcription of ribosomal protein genes. H2A.B is required for the high cell proliferation rate of Hodgkin Lymphoma cell lines. WebMar 3, 2024 · Histone H2A monoubiquitination (H2Aub1) functions as a conserved posttranslational modification in eukaryotes to maintain gene expression and guarantee … sphera observation