Webb27 maj 2024 · Off the ribosome, CAT tails act as degrons to mark those escaped RQC substrates for proteasomal degradation, independently of Ltn1. For the substrates we analyzed, Ltn1-independent degradation required the E3 ubiquitin ligase Hul5. Results CAT tails aid decay of RQC substrates Webb31 maj 2024 · In eukaryotes, this function is carried out by a dedicated surveillance mechanism known as ribosome-associated protein quality control (RQC). The E3 ubiquitin ligase Ltn1 (listerin in mammals) plays a key part in RQC by targeting the aberrant nascent polypeptides for proteasomal degradation.
Research — Brandman Lab
Webb4 feb. 2015 · Protein quality control Ribosome Fidelity in gene expression is maintained by a variety of mechanisms, including monitoring of mRNA templates and protein products. Webb28 juli 2024 · CAT-tailing is a fail-safe mechanism to ensure the degradation of partially synthesized proteins. The elongation process appears to “push” lysines out of the … healthy minds liverpool
Mechanisms and functions of ribosome-associated protein quality …
Webb28 juli 2024 · Ribosome stalling leads to recruitment of the ribosome quality control complex (RQC), which targets the partially synthesized polypeptide for proteasomal … WebbRibosome-associated quality control (RQC) and “CAT tails”, a ribosome-mediated protein modification we discovered that marks defective proteins for degradation. Learn more. “Viscoadaptation”, a homeostatic pathway we discovered that regulates viscosity, a fundamental biophysical property of the cell. Learn more. WebbRecent studies demonstrated that ribosome plays crucial roles as a hub for gene regulation and quality controls. Ribosome-interacting factors are critical for the quality control mechanisms responding to abnormal translation arrest … moto z phone issues