WebMar 1, 2004 · Efficient type 2 immunity does not develop in mice deficient in Stat6, perhaps reflecting the role of Stat6 in mediating the expression of chemokines, like CCL11 (eotaxin), CCL24 (eotaxin 2), and CCL17 (TARC), that have been associated with tissue recruitment of effector cells Hoeck and Woisetschlager 2001, Mathew et al. 2001. WebThe underlying molecular mechanisms of another Th1 type cytokine, IL-1β, induces the Muc2 activation of the p38 and ERK pathways, leading to cyclooxygenase 2 expression, an enzyme related to PGE2 synthesis. 71 Moreover, IL-4 and IL-13 are Th2 cytokines that can upregulate the expression of Muc2 through the MAPK/NF-κB mediated pathway. 72
Epithelial STAT6 O-GlcNAcylation drives a concerted anti ... - Immunity
WebNov 13, 2024 · STAT6 protein expression was detected by Western blotting, immunohistochemistry, and immunofluorescence. STAT6 mRNA expression was … WebApr 21, 2024 · Trained immunity is the ability of the innate immune system to form immune memory responses to provide support the formation of appropriate adaptive responses. Allergic airways disease (AAD) is a maladapted immune response to allergens, initiated and maintained by the type 2 (T2) inflammatory pathway. It is predicated by the elaboration of … how to lower my usaa car insurance
Sirtuin 6 maintains epithelial STAT6 activity to support intestinal ...
WebApr 10, 2024 · Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of cancer-related death across the world with the limited efficiency and response rate of immunotherapy. Protein S-palmitoylation, a powerful post-translational lipid modification, is well-known to regulate the stability and cellular distribution of cancer-related proteins, … WebSep 3, 2024 · STAT6, a transcription factor mediating type 2 immune responses, is found in the cell in its latent form. Upon cytokine stimulation it is phosphorylated by the Jak kinases at Tyr641, this leads to dimerization and translocation of STAT6 to the nucleus to induce transcription 14. WebTarget Information. STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated … journal of family \u0026 reproductive health