WebStathmin-2 has been associated with neuronal growth and regeneration, most likely due its function in microtubule dynamics. To test whether suppression of stathmin-2 increases … WebThe failure of axons to regenerate is a major obstacle for functional recovery after central nervous system (CNS) injury. Removing extracellular inhibitory molecules results in limited axon regeneration in vivo. To test for the role of intrinsic impediments to axon regrowth, we analyzed cell growth control genes using a virus-assisted in vivo conditional knockout …
Mechanism of STMN2 cryptic splice-polyadenylation and …
WebRemarkably, although loss of TDP-43 affects the levels or splicing of 1500 mRNAs, restoration of stathmin-2 to TDP-43 depleted motor neurons restored axonal regeneration capacity, strongly supporting stathmin-2 as an essential … WebStathmin-2 is anterogradely transported along axons 21 and has been implicated as an essential component for axonal regeneration 20. Upon axonal injury, stathmin-2 is upregulated and recruited to growth cones of regenerating axons 22. Moreover, stathmin-2 has been proposed as an axonal-maintenance factor whose loss accelerates a neuronal ... geometry city project parallel lines
What Is the Role of Stathmin-2 in Axonal Biology and
WebJan 14, 2024 · Stathmin-2 is anterogradely transported along axons 21 and has been implicated as an essential component for axonal regeneration 20. Following axonal injury, … WebMMRRC Strain # 070958-JAX. RRID:MMRRC_ 070958 -JAX. Common Name: Stmn2delEx3 hSTMN2. Stmn2 delEx3 hSTMN2 mice carry an Stmn2 (stathmin-like 2) knock-out allele and a transgene expressing human STMN2. In this strain, the presence of the transgene rescues the lethality phenotype found in Stmn2 delEx3 homozygous mice (MMRRC Stock No. … WebStathmin-2 (STMN2) is one of the most abundantly expressed genes in MNs. Following axonal injury, STMN2 expression is upregulated, and the protein is transported toward the growth cones of regenerating axons. STMN2 has a critical role in axonal maintenance, and its dysregulation plays an important role in neurodegenerative processes. geometry city project 4th grade