WebOct 1, 2014 · Therefore, the KCa3.1 channel may serve as a potential therapeutic target for diseases associated with cell activation and hyperproliferation, such as diabetic … WebCONCLUSIONS Given the current evidence, we propose that KCa 3.1 is a promising therapeutic target for diabetic nephropathy based on its expression and demonstrated role in fibrosis and inflammation in tubular epithelia, fibroblasts, inflammatory cells and endothelial cells, which are mechanically involved in the development of diabetic …
KCa3.1: a new player in progressive kidney disease - LWW
WebFeb 19, 2024 · Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease. Mitochondrial quality control is primarily mediated by mitochondrial … Webadults, children and young people with diabetes (type 1 or type 2) adults with an eGFR of less than 60 ml/min/1.73 m2; adults with an eGFR of 60 ml/min/1.73 m2 or more if there is a strong suspicion of CKD; children and young people without diabetes and with creatinine above the upper limit of the age-appropriate reference range joe horton no bird sing
Frontiers KCa3.1 Mediates Dysregulation of Mitochondrial Quality …
WebAug 21, 2024 · New treatment modalities or strategies are needed to prevent or slow the progression of diabetic nephropathy. KCa3.1 (also known as IK1, SK4 or KCNN4) is a … WebMar 31, 2016 · Search worldwide, life-sciences literature Search. Advanced Search WebJun 17, 2014 · Therefore targeting the possible mechanisms that drive this process may provide novel therapeutics which allow the prevention and potentially retardation of the … integrative allergy treatment near cloverdale